Apparently for one Washington State woman, the fruit was harmful to her health. The woman had a number of things going against her when she was on a grapefruit diet that caused a clot in her leg, and almost had to have it amputated! The article has been published in The Lancet.
The woman was on an oral contraceptive and the grapefruit was blocking the enzyme that normally breaks down the form of estrogen in her contraceptive.
Article here.
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